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Analysis of Metagenomic Data 2015

Workshop pages for students


Laptop Setup Instructions

Instructions for setting up your laptop can be found here: Laptop Setup Instructions


Pre-Workshop Tutorials

1) UNIX Preparation tutorials: Please complete tutorials #1-3 on UNIX at http://www.ee.surrey.ac.uk/Teaching/Unix/

2) Cytoscape Preparation tutorials: Complete the introductory tutorial to Cytoscape: http://opentutorials.cgl.ucsf.edu/index.php/Portal:Cytoscape3

  • Introduction to Cytoscape3 - User Interface
  • Introduction to Cytoscape3 - Welcome Screen
  • Filtering and Editing in Cytoscape 3

Pre-Workshop Readings


Logging into the Amazon cloud

Instructions can be found here.

  • These instructions will ONLY be valid in the classroom and not from home. The Cloud will be set up for the class.

Day 1

Module 1: Introduction to Metagenomics and Cloud Computing

*Faculty: Robert Beiko*

Lecture:

Metagenomics_2015_Module1_Lecture.pdf
Metagenomics_2015_Module1_Lecture.ppt
Metagenomics_2015_Module1_Lecture.mp4

Lab Practical:

Metagenomics Databases Lab practical

Papers:

Targeted Restoration of the Intestinal Microbiota with a Simple, Defined Bacteriotherapy Resolves Relapsing Clostridium difficile Disease in Mice
Analysis of membrane proteins in metagenomics: Networks of correlated environmental features and protein families
Ecological roles of dominant and rare prokaryotes in acid mine drainage revealed by metagenomics and metatranscriptomics
Metabolic signatures of bacterial vaginosis
Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences


Module 2: Marker Gene-based Analysis

*Faculty: William Hsiao*

Lecture:

Metagenomics_2015_Module2_Lecture.pdf
Metagenomics_2015_Module2_Lecture.ppt
Metagenomics_2015_Module2_Lecture.mp4

Lab Practical:

Marker Gene-based Lab practical

Data set:

Programs used:


Integrated Assignment - Day 1

*Faculty: Dhwani Desai and Michael Hall*

Lab Practical:

Metagenomics Integrated Assignment Metagenomics IntegratedAssignment AnswerKey


Day 2

Module 3: Metagenomic Taxonomic Composition

*Faculty: Morgan Langille*

Lecture:

Metagenomics_2015_Module3_Lecture.pdf
Metagenomics_2015_Module3_Lecture.ppt

Lab Practical:

Metagenomics Taxonomic Composition Lab Practical
Metagenomics Taxonomic Composition Lab Practical Answers

Data set:

  • Custom dataset generated from samples from the HMP DACC

Programs used:


Module 4: Metagenomic Functional Composition

*Faculty: Morgan Langille*

Lecture:

Metagenomics_2015_Module4_Lecture.pdf
Metagenomics_2015_Module4_Lecture.ppt
Metagenomics_2015_Module4_Lecture.mp4

Lab Practical:

Metagenomics Functional Composition Lab practical

Metagenomics Functional Composition Lab Answers

Data set:

  • Custom dataset generated from samples from the HMP DACC

Programs used:


Bonus Module: PICRUSt

*Faculty: Morgan Langille*

Lecture:

Metagenomics_2015_Bonus_PICRUSt_Lecture.pdf

Lab Practical:

PICRUSt Lab


Integrated Assignment - Day 2

*Faculty: Dhwani Desai and Michael Hall*

Lab Practical:

Metagenomics Integrated Assignment Integrated assignment Day 2 Answer Key


Day 3

Module 5: Metatranscriptomics

*Faculty: John Parkinson*

Lecture:

Metagenomics_2015_Module5_Lecture.pdf
Metagenomics_2015_Module5_Lecture.ppt
Metagenomics_2015_Module5_Lecture.mp4

Lab Practical:

Metatranscriptomics Lab practical


Module 6: Biomarker Selection

*Faculty: John Parkinson*

Lecture:

Metagenomics_2015_Module6_Lecture.pdf
Metagenomics_2015_Module6_Lecture.ppt
Metagenomics_2015_Module6_Lecture.mp4


Tips, tricks, and resources

Data Sets from Entire Workshops

Module2 Data
Integrated Assignment - Day 1 Data
Module3 & Module 4 Data
Integrated Assignment - Day 2 Data
Module 5 Data without blast database

Results from Instructor’s Instance on Amazon

Module2 mothur result
Module2 qiime result
Integrated Assignment - Day 1 result
Module3 result
Module4 result
Bonus Module: PICRUSt result
Integrated Assignment - Day 2 result
Module5 result

Tools with installation instructions on our Amazon server

Instructions for installing the tools used in the workshops can be found here.

Launching CBW AMI

Steps to launch CBW public AMI

  • AMI ID: ami-b7de25dc
  • AMI Name: CBW Metagenomics Workshop 2015
View on GitHub